Spiro-substituted azacycles as modulators of chemokine receptor

Details Spiro-substituted azacycles as modulators of chemokine receptor Spiro-substituted azacycles as modulators of chemokine receptor

1997-12-12

1999-10-05

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514277, 546 15, 546 16, 546 17, 546 18, A61K 3144, A61K 31435, C07D20954, C07D20956

Patent

active

059624620

ABSTRACT:
The present invention is directed to spiro-substituted azacycles of the Formula 1: ##STR1## (wherein R.sub.1, l, m, Q, W, X, Y, and Z are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

REFERENCES:
patent: 4233307 (1980-11-01), Ono et al.
patent: 5091387 (1992-02-01), Evans et al.
patent: 5536716 (1996-07-01), Chen et al.

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