Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazin

Details Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazin Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazin

1982-07-19

1983-11-22

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D40114, C07D48710, C07D47110

Patent

active

044170491

ABSTRACT:
Novel spiro-quaternary ammonium halides are disclosed. The new compounds are particularly valuable as intermediates in preparation of N-(2-pyrimidinyl)piperazinylalkyl derivatives of azaspiroalkanediones such as the psychopharmacologic agent 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dio ne.

REFERENCES:
patent: 3717634 (1973-02-01), Wu
patent: 3968216 (1976-07-01), Bouillon et al.
Babayan et al. Chem. Abs. 83, 79024(f), 1975.
Bristol-Myers, Chem. Abs. 96, 162739g, (1982).
Stogryn, Chem. Abs. 70, 57766d, (1969).
Hegar et al., Chem. Abs. 74, 14177c, (1971).

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