Spiro-polycyclicimidazolidinedione derivatives

Details Spiro-polycyclicimidazolidinedione derivatives Spiro-polycyclicimidazolidinedione derivatives

1978-11-16

1980-01-01

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548309, 548308, C07D49110, C07D49510, C07D23502

Patent

active

041817281

ABSTRACT:
Novel spiro-polycyclicimidazolidinedione derivatives useful as aldose reductase inhibitors and as therapeutic agents for the treatment of chronic diabetic complications are disclosed. The derivatives include 2',3'-dihydro-spiro[imidazolidine-4,4'-[4'H]-naphtho[1,2-b]pyran]-2,5-dion e, 2',3'-dihydro-spiro-[imidazolidine-4, 4'-[4'H]-naphtho[1,2-b]thiopyran]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-benz[a]anthracene]2,5-dion e, 2',3'-dihydro-spiro[imidazolidine-4,1'phenalene]-2,5-dione, 1',2',3',4'-tetrahydro-spiro[imidazolidine-4,1'-phenanthrene]-2,5-dione, the 2,1 isomers of the 2',3'-dihydro-4'H-pyran and 2',3'-dihydro-4'H-thiopyran derivatives, the 2',3'-dihydro-4'H-anthracenopyran and 2',3'-dihydro-4'H-anthracenothiopyran derivatives, the spiro-4,4' isomer of the tetrahydrophenanthrene derivative, the [b] isomer of the benzanthracene derivative and the mono or disubstituted 2',3'-dihydro-4'H-naphthopyran, 2',3'-dihydro-4'H-naphthothiopyran and tetrahydrophenanthrene derivatives.

REFERENCES:
patent: 2683718 (1952-01-01), Dornfield
patent: 3532744 (1970-10-01), Fletcher et al.
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4117230 (1978-09-01), Sarges
patent: 4127665 (1978-11-01), Sarges et al.
patent: 4130714 (1978-12-01), Sarges

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