Spiro[naphthalene-2(1H),2'-piperidine] and their use

Details Spiro[naphthalene-2(1H),2'-piperidine] and their use Spiro[naphthalene-2(1H),2'-piperidine] and their use

1995-03-03

1997-01-07

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544230, 546 17, 514252, 514278, 5142352, 540543, C07D22120, C07D40106, C07D41306, A61K 31445

Patent

active

055918492

ABSTRACT:
A spiro compound represented by the formula: ##STR1## wherein ring A represents an optionally substituted aromatic ring; T represents an optionally substituted hydrogen atom or an optionally substituted hydrocarbon group; X represents --CH.sub.2 --, --CO-- or --CH(OH)--; D represents --CH.sub.2 --, --O-- or --NR-- wherein R is a hydrogen atom or an optionally substituted hydrocarbon group and m, e and f independently represent an integer from 1 to 3, or a salt thereof. The spiro compound inhibits monoamine uptake, monoamine oxidase B and/or Ca ion uptake, and is a prophylactic and therapeutic drug for a central nervous diseases.

REFERENCES:
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patent: 5206240 (1993-04-01), Baldwin et al.
Crooks et al., Journal of Medicinal Chem., vol. 21, No. 6 (1978) 585-587. Month of publication not provided.
Crooks et al., Journal of Chemical Society Perkin I (1979) 2719-2726. Month of publication not provided.
Chemical Abstracts, vol. 80, No. 11 (Mar. 1974) (p. 357) 59915g.
Chemical Abstracts, vol. 82, No. 9 (Mar. 1975) (p. 578) 57732n.
Chemical Abstracts, vol. 87, No. 9 (Aug. 1977) (pp. 559-560) 68416s.
Chemical Abstracts, vol. 94, No. 17 (Apr. 1981) (p. 743) 139592d.
Chemical Abstracts, vol. 104, No. 9 (Mar. 1986) (p. 668) 68709j.

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