Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines]

Details Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines] Spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines]

1983-05-18

1984-09-18

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546 17, A61K 3155, C07D48720

Patent

active

044724144

ABSTRACT:
There are described spiro[indolo[1,7-ab][1,5]benzodiazepine-2,4'-piperidines]of the formula ##STR1## wherein p is 1 or 0, R.sub.1 is hydrogen or methyl and R is hydrogen or --CO(CH.sub.2).sub.n NR.sub.2 R.sub.3, R.sub.2 and R.sub.3 being each hydrogen or methyl but at least one of the two being methyl, and n being 1 or 2, which are useful as analgesic agents; intermediate compounds therefor; and methods for synthesizing the foregoing compounds.

REFERENCES:
patent: 4186199 (1980-01-01), Glamowski et al.
patent: 4192874 (1980-03-01), Glamowski et al.
patent: 4209625 (1980-06-01), Ong et al.
"Introduction to Organic Chemistry", by Streitweiesr and Heathcock, 2nd Edition, (Macmillan), (1981), p. 253.
"Advanced Organic Chemistry", by Royals, (Prentice-Hall), (1954), pp. 666-667.
Glamowski et al., "J. Het. Chem.", vol. 19, pp. 865-869, (1979).
Glamowski et al., "J. Med. Chem.", vol. 23, No. 12, pp. 1380-1386.

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