Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-04-01
1989-08-01
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548312, A61K 31415, C07D23372
Patent
active
048534013
ABSTRACT:
The invention relates to spirohydantoins of the formula I ##STR1## where R.sub.1 and R.sub.2 are defined hereinbelow. Also disclosed are methods of preparation, pharmaceutical compositions containing at least one of these compounds, and methods of using said compounds for treatment and prevention of complications of diabetes and galactosemia.
REFERENCES:
patent: 4117230 (1978-09-01), Sarges
patent: 4438272 (1984-03-01), York
H. G. Hers, Biochim., Biophys. Acta 37, 120-6 (1960).
Bovy Philippe R.
Gillet Claude
Lambelin Georges
Lenaers Albert
Niebes Paul
G. D. Searle & Co.
Keane J. Timothy
Matukaitis Paul D.
Schwartz Richard A.
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