Spiro derivatives, process for their preparation and medications

Details Spiro derivatives, process for their preparation and medications Spiro derivatives, process for their preparation and medications

1980-10-09

1983-02-01

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, 424279, 424285, 546 15, 548407, 549265, 549331, A61K 31445, C07D30794

Patent

active

043715389

ABSTRACT:
The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R.sub.1 and R.sub.2 represent a hydrogen atom or an alkyl group or together form a nitrogen-containing heterocyclic ring; A is a >CH.sub.2 group or a >CO group; n is 4 or 5. These compounds can be prepared from .beta.-hydroxyacids by intramolecular rearrangement by the action of a strong acid, in order to form a .gamma.-spirolactone which is converted into an .alpha.-carboxy .gamma.-spirolactone to form the compounds of formula (I) using a Mannich reaction. As necessary, a reduction is then carried out. These compounds are useful medically, in particular, as an antidepressant, a stimulant, and a neuroleptic.

REFERENCES:
patent: 2490937 (1949-12-01), Weston
patent: 2960441 (1960-11-01), Van Wessem et al.

Affiliated with

Also associated with

Rating

Spiro derivatives, process for their preparation and medications does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiro derivatives, process for their preparation and medications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro derivatives, process for their preparation and medications will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2407442