Spiro compounds, their production and use

Details Spiro compounds, their production and use Spiro compounds, their production and use

1980-09-19

1982-12-07

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

544146, 544376, 546 15, 548407, 549 45, 549 52, 549 55, 549 56, A61K 3138, C07D33364

Patent

active

043627404

ABSTRACT:
New spiro compounds of the formula: ##STR1## wherein n is an integer of 1 to 4, and X is halogen, lower alkyl, nitro, amino which may be substituted, hydroxyl which may be substituted, acyl, carboxyl, lower alkoxycarbonyl, carbamoyl which may be substituted, sulfamoyl which may be substituted, lower alkylthio or lower alkylsulfonyl, or two of X at the 5- and 6-positions together form --CH.dbd.CH--CH.dbd.CH--, exhibit inhibitory activity to thrombocyte aggregation and are useful for the prophylaxis or treatment of cardiovascular disturbance such as thrombosis.

REFERENCES:
patent: 3010971 (1961-11-01), Kaiser et al.
patent: 4105670 (1978-08-01), Noguchi et al.
patent: 4304784 (1981-12-01), Fujimara et al.
Okitsu, et al., "A Novel Ring Contraction of 4-Bromo-2,3-Dihydrobenzo-[b]thiepin-5(4H)-One", Heterocycles, vol. 6, No. 11 (1977) pp. 1877-1880.

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