Spiro compounds

Details Spiro compounds Spiro compounds

2007-04-17

2007-04-17

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S196000, C514S320000, C514S462000

Reexamination Certificate

active

10485955

ABSTRACT:
Compounds of the formula (I):(whereinA is an optionally substituted straight-chain hydrocarbon having 1 to 6 carbon atoms, which is optionally intervened by oxygen or nitrogen atom;Ar1is aryl or heteroaryl, any of which is optionally substituted;n is 0 or 1;R0is hydrogen, or lower alkylene attached to an arbitrary, bondable position of A;T, U, V and W are independently nitrogen atom or optionally substituted methine, and at least two of T, U, V and W are said methine group;X is —N(SO2R1)—, —N(COR2)— or —CO—;Y is —C(R3)(R4)—, —O— or —N(R5)—;Z is methine or nitrogen atom) exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, etc., sexual and reproductive dysfunctions, and gastro-intestinal motility disorder.

REFERENCES:
patent: 5869489 (1999-02-01), Shah et al.
patent: 6191160 (2001-02-01), Gao et al.
patent: 6326375 (2001-12-01), Fukami et al.
patent: 6803372 (2004-10-01), Fukami et al.
patent: 6939966 (2005-09-01), Burns et al.
patent: 1 323 709 (2003-07-01), None
patent: 2 311 523 (1997-10-01), None
patent: 99/22735 (1999-05-01), None
patent: 00/27845 (2000-05-01), None
patent: 01/14328 (2001-03-01), None
patent: 01/14376 (2001-03-01), None
patent: 02/48152 (2002-06-01), None
H. Qi et al., “L-Tryptophan Urea, Amides as NK1/NK2Dual Antagonists”, Bioorganic & Medicinal Chemistry Letters, vol. 8, 1998, No. 16, pp. 2259-2262.
A. Poulsen et al., “A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes”, Journal of Computer-Aided Molecular Design, vol. 16, No. 4, pp. 273-286, 2002.

Affiliated with

Also associated with

Rating

Spiro compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spiro compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3773809