Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-19
2008-11-18
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S029000, C549S030000, C549S035000, C514S430000, C514S438000
Reexamination Certificate
active
07452914
ABSTRACT:
The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
REFERENCES:
patent: WO 02/053522 (2002-07-01), None
patent: WO 02/053522 (2002-07-01), None
patent: WO 02/066428 (2002-08-01), None
patent: WO 02/066428 (2002-08-01), None
patent: WO 2004/094400 (2004-11-01), None
patent: WO 2004/094400 (2004-11-01), None
Albert, J.L. et al.: “Estrogen Regulation of Placental Alkaline Phosphatase Gene Expression in a Human Endometrial Adenocarcinoma Cell Line”; Cancer Research (Jun. 1, 1990) 50: 3306-3310.
Welshons, W.V. et al.: “Stimulation of breast cancer cells in vitro by the environmental estrogen entrolactone and the phytoestrogen equol”; Breast Cancer Research and Treatment (1987) 10: 169-175.
Sui Zhihua
Zhang Xuqing
Janssen Pharmaceutica N.V.
Shameem Golam M
LandOfFree
Spiro-benzo[c]chromene derivatives useful as modulators of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Spiro-benzo[c]chromene derivatives useful as modulators of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spiro-benzo[c]chromene derivatives useful as modulators of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4050341