Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-03-23
2000-04-04
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3140, A61K 31445
Patent
active
060461950
DESCRIPTION:
BRIEF SUMMARY
This invention relates to a class of azacyclic compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are spiro-substituted azacyclic derivatives.
International (PCT) patent specification no. WO 94/20500 (published Sep. 15th, 1994) discloses spiroazacyclic derivatives as substance P antagonists. In particular, WO 94/20500 relates to spirocyclic piperidine derivatives containing a 1,8-diazaspiro[5.5]undecane core.
We have now found a further class of non-peptides which are potent antagonists of tachykinins, especially of substance P.
The present invention provides compounds of the formula (I): ##STR1## wherein
R.sup.1 represents hydrogen, hydroxy, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, fluoroC.sub.1-6 alkyl, C.sub.1-6 alkoxy, fluoroC.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-4 alkyl, C.sub.1-6 alkoxyC.sub.1-4 alkoxy, fluoroC.sub.1-6 alkoxyC.sub.1-4 alkyl, C.sub.2-6 alkenyloxy, C.sub.3-7 cycloalkoxy, C.sub.3-7 cycloalkylC.sub.1-4 alkoxy, phenoxy, benzyloxy, cyano, halogen, NR.sup.11 COR.sup.14, NR.sup.a R.sup.b, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, OSO.sub.2 R.sup.a, or C.sub.1-4 alkyl substituted by cyano or CO.sub.2 R.sup.a, where R.sup.a and R.sup.b each independently represent hydrogen, C.sub.1-4 alkyl or fluoroC.sub.1-4 alkyl;
R.sup.2 represents hydrogen, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;
or when R.sup.2 is adjacent to R.sup.1, they may be joined together such that there is formed a 5- or 6-membered saturated or unsaturated ring containing one or two oxygen atoms;
R.sup.3 represents a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms, selected from nitrogen, oxygen and sulphur, which group is optionally substituted by one or two groups selected from halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, trifluoromethyl, trifluoromethoxy, nitro, cyano, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, COR.sup.a, CO.sub.2 R.sup.a, phenyl, --(CH.sub.2).sub.r NR.sup.a R.sup.b, --(CH.sub.2).sub.r NR.sup.a COR.sup.b, --(CH.sub.2).sub.r CONR.sup.a R.sup.b, or CH.sub.2 C(O)R.sup.a, where R.sup.a and R.sup.b are each independently hydrogen or C.sub.1-4 alkyl and r is zero, 1 or 2;
R.sup.4 represents hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or C.sub.1-4 alkyl substituted by C.sub.1-4 alkoxy, where R.sup.a and R.sup.b each independently represent hydrogen or C.sub.1-4 alkyl;
R.sup.5 represents hydrogen, halogen, C.sub.1-6 alkyl, trifluoromethyl or C.sub.1-6 alkoxy substituted by C.sub.1-4 alkoxy;
R.sup.6 represents hydrogen, COR.sup.a, CO.sub.2 R.sup.a, COCONR.sup.a R.sup.b, COCO.sub.2 R.sup.a, C.sub.1-6 alkyl optionally substituted by a group selected from (CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, hydroxy, cyano, COR.sup.a, NR.sup.a R.sup.b, C(NOH)NR.sup.a R.sup.b, CONHphenyl(C.sub.1-4 alkyl), COCO.sub.2 R.sup.a, CONHNR.sup.a R.sup.b, C(S)NR.sup.a R.sup.b, CONR.sup.a C.sub.1-6 alkylR.sup.12, CONR.sup.13 C.sub.2-6 alkenyl, CONR.sup.13 C.sub.2-6 alkynyl, COCONR.sup.a R.sup.b, CONR.sup.a C(NR.sup.b)NR.sup.a R.sup.b, CONR.sup.a heteroaryl, and phenyl optionally substituted by one, two or three substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen and trifluoromethyl), where R.sup.a and R.sup.b are each independently hydrogen or C.sub.1-4 alkyl;
or R.sup.6 represents a group of the formula --CH.sub.2 C.tbd.CCH.sub.2 NR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 are as defined below;
or R.sup.6 represents C.sub.1-6 alkyl, optionally substituted by oxo, substituted by a 5-membered or 6-membered heterocyclic ring containing 1, 2 or 3 nitrogen atoms optionally substituted by .dbd.O or .dbd.S and optionally substituted by a group of the formula ZNR.sup.7 R.sup.8 where
Z is C.sub.1-6 alkylene or C.sub.3-6 cycloalkyl;
R.sup.7 is hydrogen or C.sub.1-4 alkyl, C.s
REFERENCES:
patent: 5688806 (1997-11-01), Desai et al.
Haworth Karen Elizabeth
Seward Eileen Mary
Swain Christopher John
Merck Sharp & Dohme Ltd.
Patel Sudhaker
Raymond Richard L.
Rose David L.
Thies J. Eric
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