Spiral vane bioreactor

Details Spiral vane bioreactor Spiral vane bioreactor

1988-11-29

1991-03-26

Lacey, David L.

Chemistry: molecular biology and microbiology

Apparatus

Including condition or time responsive control means

435289, 435311, 435315, 435316, 210396, C12M 0306

Patent

active

050028901

ABSTRACT:
A spiral vane bioreactor of a perfusion type in which a vertical chamber (10), intended for use in a microgravity condition, has a central rotating filter assembly (30) and has flexible membranes (56) disposed to rotate annularly about the filter assembly. The flexible members have end portions disposed angularly with respect to one another. A fluid replenishment medium is input (68) from a closed loop liquid system to a completely liquid filled chamber containing microcarrier beads, cells and a fluid medium. Output (36) of spent medium is to the closed loop. In the closed loop, the output and input parameters are sensed by sensors (82,96); a manifold 86 permits recharging of the nutrients and pH adjustment; oxygen is supplied and carbon dioxide removed, bubbles are removed and the system is monitored and controlled by a microprocessor (100).

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