Spinal muscular atrophy diagnostic methods

Details Spinal muscular atrophy diagnostic methods Spinal muscular atrophy diagnostic methods

2006-04-25

2006-04-25

Hayes, Robert C. (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200

Reexamination Certificate

active

07033752

ABSTRACT:
The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene.

REFERENCES:
Rudinger, In “Peptide Hormones” (ed. J.A. Parsons) University Park Press, Baltimore, pp. 1-7, 1976.
Stratagene Cloning Systems Catalog, catalog #300385, p. 103, 1994.
Cross et al.,Nature Genetics, 6 (1994) pp. 236-244.
Das et al.,J. of Biological Chemistry, 260 (1985) pp. 6240-6247.
Stratagene Product Catalog(1991) p. 66.

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