Surgery – Instruments – Surgical mesh – connector – clip – clamp or band
Reexamination Certificate
2007-01-16
2007-01-16
Hayes, Michael J. (Department: 3734)
Surgery
Instruments
Surgical mesh, connector, clip, clamp or band
C606S153000, C606S154000, C606S155000, C424S423000, C424S426000
Reexamination Certificate
active
10629427
ABSTRACT:
An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.
REFERENCES:
patent: 4273920 (1981-06-01), Nevin
patent: 4870966 (1989-10-01), Dellon et al.
patent: 5061281 (1991-10-01), Mares et al.
patent: 5358475 (1994-10-01), Mares et al.
patent: 5656605 (1997-08-01), Hansson et al.
patent: 5681568 (1997-10-01), Goldin et al.
patent: 5736132 (1998-04-01), Juergensen et al.
patent: 5874099 (1999-02-01), Dionne et al.
patent: 5925053 (1999-07-01), Hadlock et al.
patent: 6063378 (2000-05-01), Nohara et al.
patent: 6132360 (2000-10-01), Halpern
patent: 6214021 (2001-04-01), Hadlock et al.
patent: 6241771 (2001-06-01), Gresser et al.
patent: 6362308 (2002-03-01), Pham
patent: 6368630 (2002-04-01), Bernstein et al.
patent: 6471993 (2002-10-01), Shastri et al.
patent: 6716225 (2004-04-01), Li et al.
patent: 6972168 (2005-12-01), Muir
patent: 2002/0051806 (2002-05-01), Mallapragada et al.
patent: 2002/0086047 (2002-07-01), Mueller et al.
Olmarker et al., “Chondroitinase ABC (Pharmaceutical Grade) for Chemonucleolysis”, Spine, 1996. 21:1952-56.
Bradbury et al., “Chondroitinase ABC promotes functional recovery after spinal cord injury”, Nature, Apr. 11, 2002, 416:636-40.
Zuo et al., “Regeneration of Axons after Nerve Transection Repair is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan”, Exp. Neurol., 2002. 176:221-28.
Oldham et al., “Biological Activity of rhBMP-2 Released from PLGA Microspheres”, Journal of Biomechanical Engineering, 2000. 122:289-292.
Farndale, “Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue”, Biochemica et Biopphysica Acta, 1986. 883:173-77.
Friedman Jonathan A.
Moore Michael J.
Windebank Anthony J.
Yaszemski Michael J.
Hayes Michael J.
Mayo Foundation for Medical Education and Research
Mendoza Michael G.
Quarles & Brady LLP
LandOfFree
Spinal cord surgical implant does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Spinal cord surgical implant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spinal cord surgical implant will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3749807