Spinal cord surgical implant

Surgery – Instruments – Surgical mesh – connector – clip – clamp or band

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C606S153000, C606S154000, C606S155000, C424S423000, C424S426000

Reexamination Certificate

active

10629427

ABSTRACT:
An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.

REFERENCES:
patent: 4273920 (1981-06-01), Nevin
patent: 4870966 (1989-10-01), Dellon et al.
patent: 5061281 (1991-10-01), Mares et al.
patent: 5358475 (1994-10-01), Mares et al.
patent: 5656605 (1997-08-01), Hansson et al.
patent: 5681568 (1997-10-01), Goldin et al.
patent: 5736132 (1998-04-01), Juergensen et al.
patent: 5874099 (1999-02-01), Dionne et al.
patent: 5925053 (1999-07-01), Hadlock et al.
patent: 6063378 (2000-05-01), Nohara et al.
patent: 6132360 (2000-10-01), Halpern
patent: 6214021 (2001-04-01), Hadlock et al.
patent: 6241771 (2001-06-01), Gresser et al.
patent: 6362308 (2002-03-01), Pham
patent: 6368630 (2002-04-01), Bernstein et al.
patent: 6471993 (2002-10-01), Shastri et al.
patent: 6716225 (2004-04-01), Li et al.
patent: 6972168 (2005-12-01), Muir
patent: 2002/0051806 (2002-05-01), Mallapragada et al.
patent: 2002/0086047 (2002-07-01), Mueller et al.
Olmarker et al., “Chondroitinase ABC (Pharmaceutical Grade) for Chemonucleolysis”, Spine, 1996. 21:1952-56.
Bradbury et al., “Chondroitinase ABC promotes functional recovery after spinal cord injury”, Nature, Apr. 11, 2002, 416:636-40.
Zuo et al., “Regeneration of Axons after Nerve Transection Repair is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan”, Exp. Neurol., 2002. 176:221-28.
Oldham et al., “Biological Activity of rhBMP-2 Released from PLGA Microspheres”, Journal of Biomechanical Engineering, 2000. 122:289-292.
Farndale, “Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue”, Biochemica et Biopphysica Acta, 1986. 883:173-77.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Spinal cord surgical implant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Spinal cord surgical implant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spinal cord surgical implant will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3749807

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.