Sphingosomes for enhanced drug delivery

Details Sphingosomes for enhanced drug delivery Sphingosomes for enhanced drug delivery

1994-06-20

1996-08-06

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 27, 514283, A61K 9127, A61K 3144

Patent

active

055431526

ABSTRACT:
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.

REFERENCES:
patent: 4920016 (1990-04-01), Allen et al.
patent: 5192549 (1993-03-01), Barenholz et al.
Hope et al, "Generation of Multilamellar and Unilamellar Phospholipid vesicles", Chemistry and Physics of Lipids, 40 (1986), 89-107.

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