Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1997-09-17
1998-09-29
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
A61K 9127, A61K 3144
Patent
active
058143351
ABSTRACT:
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.
REFERENCES:
patent: 4920016 (1990-04-01), Allen
patent: 4981692 (1991-01-01), Popescu et al.
patent: 5192549 (1993-03-01), Barenholz et al.
Hope et al., "Generation of Multilamellar and Unilamellar Phospholipid Vesicles," Chemistry and Physics of Lipids, 40:89-107 (1986).
Bally Marcel B.
Mayer Lawrence D.
Miller James J.
Tardi Paul G.
Webb Murray S.
Inex Pharmaceuticals Corporation
Nutter Nathan M.
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