Sphingosine kinase inhibitors

Details Sphingosine kinase inhibitors Sphingosine kinase inhibitors

2006-06-15

2008-03-04

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S285000

Reexamination Certificate

active

07338961

ABSTRACT:
The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

REFERENCES:
patent: 3352912 (1967-11-01), Prichard
patent: 3657273 (1972-04-01), Krimmel
patent: 3663565 (1972-05-01), Krimmel
patent: 4053509 (1977-10-01), Faro et al.
patent: 4332806 (1982-06-01), Atsumi et al.
patent: 4349552 (1982-09-01), Takaya et al.
patent: 5595995 (1997-01-01), Chan et al.
patent: 6649600 (2003-11-01), Kiesman et al.
patent: 2004/0034075 (2004-02-01), Smith et al.
patent: 2006/0270630 (2006-11-01), Smith et al.
patent: 2006/0270631 (2006-11-01), Smith et al.
patent: WO 99/26927 (1999-06-01), None
patent: WO 2004/089470 (2004-10-01), None
patent: WO 2006/048750 (2006-05-01), None
patent: WO 2006/100502 (2006-09-01), None
Johnson, A. W. Invitation to Organic Chemistry 1999 Jones and Bartlett: Mississauga, Canada, p. 24.
Hal Bender “Nomenclature”, Clackamas Community College online: “http://dl.clackamas.cc.or.us/ch106-05
omencia1.htm2003”, May 5, 2007.
“R-5.7.8 Amides, imides, and hydrazides” online “http://www.acdlabs.com/iupac
omenclature/93/r93—543.htm”, May 2, 2007.
Ferdinand C. Y. Chan, Gerard A. Potter, S. Elaine Barrie, Benjamin P. Haynes, Martin G. Rowlands, John Houghton, and Michael Jarman “3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P450” . . . “Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer” Journal of Medicinal Chemistry 1996, 39, 3319-3323.
Charles Price “The alkylation of aromatic compounds by the Friedel-crafts method” In Organic Reactions vol. III, WIley: New York, 1947, 1-19.
Handa, I. et. al. Journal of Chemical Engineering Data 1984, 29, 223-225.
Melindez et. al. “Sphingosine kinase signalling in immune cells: Potential as novel therapeutic targets” Biochimica et Biophysica Acta 2007, in press.
El-Sherbeny M A: “Adamantane Derivatives, Part II: Synthesis DNA Binding and Antitumor Evaluation;” Medicinal Chemistry Research 2002 United States; vol. 11, No. 2, 2002, pp. 74-86.
Makarova, N.V. et al: “Dimethyl Adamantoylmalonate: New Intermediate In The Synthesis of 1-Acetyladamantane;” Russian Journal of Organic Chemistry.
Kozlov N.G. et al.; “Reductive Amination of 1-Acetyladamantane With Nitriles;” Chemical Abstracts Service, Columbus, Ohio; retrieved from STN Database accession No. 1985:504596.
SciFinder substructure search results, aminoethylpyridine, performed Aug. 9, 2007, 26 pages.
SciFinder substructure search results, aminomethylpyridine (commercially available only), performed Aug. 9, 2007, 21 pages.
International Search Report for PCT/US2006/023645.
Danilenko, G. N. et al.; Synthesis and Biological Activity of Adamantane Derivatives; Pharmaceutical Chemistry Journal English Translation of Khimiko—Farmatsevticheskii Zhurnal, vol. 7, No. 10, pp. 621-622, Oct. 1973.
Safonova, O.A. et al.; Synthesis and Biological Activity of 5-(Adamant-1-yl)Salicylic Acid, 3-(4-Hydroxyphenyl) adamentanecarboxylic Acid and Some of their Derivatives; Translated from Khimiko-farmatsevticheskii Zhurnal, vol. 23, no. 9, pp. 1094-1098, Sep. 1989.
Handa, Indra et al.; Synthesis of 3-Aryl-1-adamantanemethylamines; J. Chem. Eng. Data 1984, 29, 223-225.
Danilenko, G. I. et al.; Bacteriostatic effect of adamantanecarboxylic acids; Fiziologicheski Aktivnye Veshchestva (1966-1992) (1975), 7, 144-7; Chemical Abstracts accession No. 1975:496537.
Pozdnyakov, V. V. et al.; Synthesis and Reactivity of 3-R-1-Adamantyl Methyl Ketones; Russian Journal of Organic Chemistry, vol. 37, No. 9, 2001 pp. 1128-1231.
Fytas, George et al; 3-Cyclopentyl-1-Adamantanamines and Adamantanemethanamines. Antiviral Activity Evaluation and Convulsions Studies; IL Farmaco, 49 (10), 641-647 (1994).
Stepanov, F. N. et al; Adamantane and its derivatives. XXV. Reaction of bromomethyl ketones of adamantanes with formamide and aniline; (Translated from Zhurnal Organicheskoi Khimii (1970), 6(6), 1195-8).
Scvekhgeimer, G.A. et al.; Synthesis and properties of azoles and their deriivatives. XXX. Synthesis of heterocyclic compounds based on adamantane-1,3-dicarboxylic acid dinitrile; Khimiya Geterotsiklicheskikd Soedinenii (1976), (12), 1654-7.
Kontonassios, Demetrios et al.; 3-(Dialkylamino)methyladamantane-1-carboxylic Acids; Journal of Medical Chemistry, vol. 12, No. 1, pp. 170-172, Jan. 1969.
Frisherman, R. B. et al; N-Methylstearylamides of adamantanecarboxylic acids; U.S.S.R. Otkrytiya, Izobret., Prom. Obraztsy, Tovarnye Znaki 1974, 51(44), 51-2.
No, B.I. et al; Synthesis of N,N′-diphenyl-1-1,3-adamantanebis (carboximidoyl chloride) and adamantanebis (carboximidates); Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (1999), 69(5), 843-844.
Horvat, Śtefica; Tumor-Cell-Targeted Methionine-enkephalin Analogues Containing Unnatural Amino Acids: Design, Synthesis, and in Vitro Antitumor Activity; J. Med. Chem. 2006, 49, 3136-3142.

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