Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1995-01-12
1997-09-02
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
C07F 909
Patent
active
056634048
ABSTRACT:
A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
REFERENCES:
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A.S. Bushnev et al., Bioorg. Khim. 5 (9), 1381-1384 (1979).
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Hakomori Sen-itiroh
Igarashi Yasuyuki
Kawa Shigeyuki
Ruan Fuqiang
Sadahira Yoshito
Ambrose Michael G.
Oncomembrane
Richter Johann
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