Spheroid formulation

Details Spheroid formulation Spheroid formulation

1994-12-05

1997-04-22

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

A61K 936, A61K 916

Patent

active

056227221

ABSTRACT:
A pharmaceutical composition comprising spheroids comprising a water-soluble active ingredient or a pharmaceutically acceptable salt thereof, microcrystalline cellulose and a sugar. Preferably the active ingredient is hydromorphone hydrochloride and the sugar is lactose. Surprisingly the incorporation of a sugar improves the dissolution rate of the spheroid formulation instead of reducing the dissolution rate by competing with the active ingredient for solubilization.

REFERENCES:
patent: 4867785 (1989-09-01), Heafield et al.
patent: 4990341 (1991-02-01), Goldie et al.
patent: 5049394 (1991-09-01), Howard et al.
patent: 5350584 (1994-09-01), McClelland et al.

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