Spherically agglomerated starches with silicon dioxide

Details Spherically agglomerated starches with silicon dioxide Spherically agglomerated starches with silicon dioxide

1996-08-27

1999-03-30

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514951, A61K 916

Patent

active

058885480

ABSTRACT:
Granules of starch or low protein rice flour are agglomerated to a larger size and a spherical shape by combining the granules with silicon dioxide and water to form a slurry, and drying the slurry by a spray dryer. The agglomerates have better flowability than the granules, and are readily used as direct compression fillers for tablets and capsules in drug or nutrient formulations. Tablets formed from these agglomerates have good hardness and friability, as well as favorable disintegration and dissolution characteristics. Chemically or physically modified starches can also be used, and starches other than rice starches can be included as well.

REFERENCES:
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patent: 5047246 (1991-09-01), Gallian et al.
patent: 5585115 (1996-12-01), Sherwood et al.
Mitrevej et al. Production of Modified Rice Starch and its Utilization in the Pharmaceutical Industry. Micro. Util. Renewable Resource. 1989, vol. 6, pp. 153-157. Full Document.
Varavinit et al. Production of Spray Dried Rice Starch and its Utilization in the Pharmaceutical Industry. Microb. Util. Renewable Resource. 1989, vol. 6, pp. 158-162. Full Document.
Chemical Abstract Assession No. 113:218073, 1989.
Chemical Abstract Assession No. 113:218074, 1989.

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