Spherical seed cores, spherical granules and process for product

Details Spherical seed cores, spherical granules and process for product Spherical seed cores, spherical granules and process for product

1993-01-12

1995-01-24

Thibodeau, Paul J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424463, 424464, 424490, 428402, 428403, 428533, 514781, 5147881, 514951, 514960, 514961, A61K 962, B32B 516

Patent

active

053841301

ABSTRACT:
Pharmacologically inactive spherical seed cores comprising at least 50% by weight of microcrystalline cellulose having an average degree of polymerization of 60 to 375, wherein the spherical seed cores have an average particle size of 100 to 1000 .mu.m, a tapped bulk density of at least 0.65 g/ml, an aspect ratio of at least 0.7, a water absorption capacity of 0.5 to 1.5 ml/g, and a friability of no more than 1%; spherical granules comprising the spherical seed cores coated with a powdery layer comprising active ingredients and having an outer layer of coating provided on the powdery layer; and a process for the production of spherical granules, comprising the steps of coating the spherical seed cores with powder comprising active ingredients using an aqueous binding solution, spraying an aqueous solution or suspension of a coating agent thereon, and drying the resulting coated granules.

REFERENCES:
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patent: 4867985 (1989-09-01), Heafield et al.
patent: 4900558 (1990-02-01), Barry et al.
patent: 5026560 (1991-06-01), Makino et al.
European Search Report, EP 91 10 5993, Jan. 5, 1993.
Patent Abstracts of Japan, vol. 11, No. 47 (C-403) (2492) published Feb. 13, 1987.

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