Sperm specific proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07094547

ABSTRACT:
The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contraceptive applications.

REFERENCES:
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patent: WO 99/11293 (1999-03-01), None
patent: WO 00/12708 (2000-03-01), None
patent: WO 01/42451 (2000-12-01), None
Hao et al., “SAMP32, a Testis-Specific, Isoantigenic Sperm Acrosomal Membrane-Associated Protein,” Biology of Reproduction 66, 735-744 (2002).
Schellenberger, V., Turck, C. W., Hedstrom, L. and Ritter, W. J. (1993). Mapping the S' Subsites of Serine Proteases Using Acyl Transfer to Mictures of Peptide Mucleophiles. Biochemistry, vol. 32, pp. 4349-4353.
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O'Hern, Patricia A. et al: “Reversible Contraception in Female Baboons Immunized with a Synthetic Epitope of Sperm-Specific Lactate Dehydrogenase”, Biology of Reproduction, vol. 52, pp. 331-339, (1995).
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Database Geneseq [Online], Accession No. AAV63171, Jan. 12, 1999, Agostino MJ, et al.: “cDNA from clone cf50—1 which encodes a secreted protein”.
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Chen, Michellee S., et al.: “Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin a6b1: Implications for Murine Fertilization”, PNAS, vol. 96, No. 21, pp. 11830-11835, Oct. 12, (1999).
Le Noir, Francois, et al.: “Severely Reduced Female Fertility in CD9-Deficient Mice”, SCIENCE, vol. 287, Jan. 14, (2000).
Diekman, Alan B. et al,: “N-linked glycan of a sperm CD52 glycoform associated with human infertility”, FASEB, vol. 13, pp. 1303-1308, Aug. (1999).
Miyado, Kenji, et al.: “Reguirement of CD9 on the Egg Plasma Membrane for Fertilization”, SCIENCE, vol. 287, Jan. 14, (2000).

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