Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1995-05-08
1997-04-01
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4241841, 4241851, 4241931, 4242781, 530300, 530350, A61K 3900
Patent
active
056163223
ABSTRACT:
The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigeenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.
REFERENCES:
patent: 5175148 (1992-12-01), O'Rand et al.
R.T. Richardson, et al; Cloning and Sequencing of the Rabbit Sperm Zona Binding Protein, RSA-3; Presence of a Sulfate Binding Region, Mol. Biol. Cell 3 No. 15a (1992).
R.B. Shabanowitz et al; Molecular Changes in the Human Zona Pellucida Associated with Fertilization and Human Sperm-Zona Interactions, Ann. N.Y. Acad. Sci. 541, pp. 621-632 (1988).
Lea Isabel A.
O'Rand Michael G.
Richardson Richard T.
Widgren Esther E.
Nucker Christine M.
Scheiner Laurie
The University of North Carolina at Chapel Hill
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