Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-05-08
1998-10-13
Scheiner, Laurie A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4241851, 4242781, 435 71, 435 721, 435 792, 4352523, 530324, 530325, 530326, 530327, 530328, 530329, 530300, 530350, 436501, A61K 3800
Patent
active
058208615
ABSTRACT:
The present invention involves DNA encoding a mammalian Sp 17 protein, particularly human Sp17 protein, or antigenic peptides which are fragments thereof, along with said antigenic fragments. These proteins and peptides are useful as immunocontraceptive agents and/or for the diagnosis of autoimmune infertility. Avirulent host cells which express the antigenic proteins or peptides and which are useful as immunocontraceptive agents are also disclosed.
REFERENCES:
patent: 5175148 (1992-12-01), O'Rand et al.
Andersson et al., Nature, 354:159-161 (1991).
Suzuki et al, J. Biochem., 108:344-346 (1990).
Hill et al., Natur, 311:175-177 (1984).
Ohkubo et al., Biochem. J., 276:337-342 (1991).
"MPSRCH.TM." Results of protein database search referencing 13 Jan. 1995 submission of Richardson et al.
R.T. Richardson, et al; Cloning and Sequencing of the Rabbit Sperm Zona Binding Protein, RSA-3; Presence of a Sulfate Binding Region, Mol. Biol. Cell 3 No. 15a (1992).
R.B. Shabanowitz et al; Molecular Changes in the Human Zona Pellucida Associated with Fertilization and Human Sperm-Zona Interactions, Ann N.Y. Acad. Sci. 541, pp. 621-632 (1988).
Lea Isabel A.
O'Rand Michael G.
Richardson Richard T.
Widgren Esther E.
Scheiner Laurie A.
The University of North Carolina at Chapel Hill
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