Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1989-11-24
1992-12-29
Rosen, Sam
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 88, 436501, 436543, 514 2, 514 14, 514841, 530326, 530327, 530328, A61K 3702, C07K 706, G01N 33566
Patent
active
051751488
ABSTRACT:
Disclosed is a synthetic peptide, useful as an immunocontraceptive agent and for the diagnosis of autoimmune infertility, which corresponds to an autoantigenic epitope of Rabbit Sperm Membrane Autoantigen (RSA). The synthetic peptide is selected from the group consisting of the decapeptide NH.sub.2 -pro-gly-gly-gly-thr-leu-pro-pro-ser-gly-COOH and the antigenic equivalents thereof.
Also disclosed is a method of diagnosing autoimmune infertility in a human subject. The method comprises the step of, first, contacting an immune sera sample from the subject with an antigen, the antigen selected from the group consisting of RSA, other proteins which bind selection antibodies which bind to RSA, and derivatives thereof which bind selection antibodies which bind to RSA. The next step is to detect the presence of antibodies from the immune sera sample bound to the antigen, the presence of antibodies bound to the antigen suggesting the subject is afflicted with autoimmune infertility. A preferred group of antigens is the decapeptide NH.sub.2 -pro-gly-gly-gly-thr-leu-pro-pro-ser-gly-COOH and the antigenic equivalents thereof.
REFERENCES:
patent: 4857634 (1989-08-01), Minor et al.
O'Rand, M. and Porter, J., "Isolation of a Sperm Membrane Sialoglycoprotein Autoantigen from Rabbit Testes," The Journal of Immunology 122, No. 4, 1248 (1979).
O'Rand, M. and Porter, J. "Isolation of Rabbit Sperm Immobilizing Autoantigens from Immunoabsorbent Chromatography," Biol. Reprod. Supplement 18, No. 1, 119 (1978).
O'Rand, M. and Porter, J. "Purification of Rabbit Sperm Autoantigens by Preparative SDS Gel Electrophoresis: Amino Acid and Carbohydrate Content of RSA-1," Biology of Reproduction 27, 713 (1982).
O'Rand, M. et al., "Monoclonal Antibodies to Rabbit Sperm Autoantigens, I, Inhibition of In Vitro Fertilization and Localization on the Egg," Biology of Reproduction 30, 721 (1984).
O'Rand, M. and Irons, G., "Monoclonal Antibodies to Rabbit Sperm Autoantigens, II, Inhibition of Human Sperm Penetration of Zona-Free Hamster Eggs," Biology of Reproduction 30, 731 (1984).
O'Rand, M. et al., "Characterization of the Rabbit Sperm Membrane Autoantigen, RSA, as a Lectin-like Zona Binding Protein," Developmental Biology 129, 231 (1988).
Welch, J. et al., "Isolation of a Testis Specific cDNA with Alloantiserum to a Rabbit Sperm Membrane Autoantigen, RSA-1," J. Cell Bilogy 103, 482a (1986).
O'Rand Michael G.
Widgren Esther E.
Rosen Sam
The University of North Carolina at Chapel Hill
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