Surgery – Truss – Pad
Patent
1994-12-30
1998-01-13
Casler, Brian L.
Surgery
Truss
Pad
128664, 128633, 356 40, 356433, 250330, A61B 600
Patent
active
057068216
ABSTRACT:
A spectrometric technique is described for quantitatively determining the change in concentration of a substance which is contained in a medium which both absorbs and scatters spectroscopically interrogated radiation, and in particular to the specific case in which the change in concentration of the substance occurs in one spatially distinct region of the medium. The medium includes a plurality of such regions displaying potentially different absorption and scattering properties to the radiation. Specific applications are disclosed involving the noninvasive determination of changes in concentration of the substances oxyhemoglobin and deoxyhemoglobin and/or changes in the redox state of the substance cytochrome oxidase within the brain or skeletal muscle, and in cases where the brain or skeletal muscle is interrogated by radiation in the near-infrared part of the electromagnetic spectrum through intervening surface tissues, i.e., cortical bone or adipose tissue, where it may be assumed that no changes of concentration of said substances occur within said surface tissues.
REFERENCES:
patent: 4805623 (1989-02-01), Jobsis
Chance et al, "A Phase Modulation System for Dual Wavelength Difference Spectroscopy of Hemoglobin Deoxygenation in Tissues", University of Pennsylvania, Department of Biochemistry and Biophsysics, Phildelphia, PA 19104, no date.
Wary et al, "Characterization of the Near Infrared Absorption Spectra of Cytochroms aa.sub.3 and Haemoglobin for the Non-Invasive Monitoring of Cerebral Oxygenation", Biochim. Biophys. Acta. 933 (1988) pp. 184-192.
Hiraoka et al, "A Monte Carlo Investigation of Optical Pathlength in Inhomogeneous Tissue and its Application to Near-Infrared Spectroscopy", Phys. Med. Biol. 38 (1993), pp. 1859-1876.
Matcher et al, "Use of the Water Absorption Spectrum to Quantify Tissue Chromophore Concentration Changes in Near-Infrared Spectroscopy", Phys. Med. Biol. 38 (1994) pp. 177-196.
Cope Mark
Delpy David Thomas
Matcher Stephen John
Casler Brian L.
Hamamatsu Photonics K.K.
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