Spectrometer provided with pulsed ion source and...

Details Spectrometer provided with pulsed ion source and... Spectrometer provided with pulsed ion source and...

2007-03-13

2007-03-13

Nguyen, Kiet T. (Department: 2881)

Radiant energy

Ionic separation or analysis

C250S287000

Reexamination Certificate

active

10919859

ABSTRACT:
A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.

REFERENCES:
patent: 5962851 (1999-10-01), Whitehouse et al.
patent: 6833543 (2004-12-01), Krutchinsky et al.

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