Spectral imaging of deep tissue

Details Spectral imaging of deep tissue Spectral imaging of deep tissue

2008-01-22

2008-01-22

Casler, Brian L. (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C600S310000, C600S473000, C600S475000, C356S432000

Reexamination Certificate

active

10669101

ABSTRACT:
Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

REFERENCES:
patent: 4379233 (1983-04-01), Rosenthal
patent: 4519707 (1985-05-01), Kuffer
patent: 4669878 (1987-06-01), Meier
patent: 4800279 (1989-01-01), Hieftji et al.
patent: 5029245 (1991-07-01), Keranen et al.
patent: 5042893 (1991-08-01), Ong
patent: 5066124 (1991-11-01), Wulf
patent: 5137364 (1992-08-01), McCarthy
patent: 5424545 (1995-06-01), Block et al.
patent: 5433197 (1995-07-01), Stark
patent: 5507287 (1996-04-01), Palcic et al.
patent: 5539517 (1996-07-01), Cabib et al.
patent: 5567937 (1996-10-01), Pinkus
patent: 5608213 (1997-03-01), Pinkus et al.
patent: 5647368 (1997-07-01), Zeng et al.
patent: 5719024 (1998-02-01), Cabib et al.
patent: 5760407 (1998-06-01), Margosiak et al.
patent: 5827190 (1998-10-01), Palcic et al.
patent: 5838451 (1998-11-01), McCarthy
patent: 5912165 (1999-06-01), Cabib et al.
patent: 5991028 (1999-11-01), Cabib et al.
patent: 5995645 (1999-11-01), Soenkson et al.
patent: 5999844 (1999-12-01), Gombrich et al.
patent: 6007996 (1999-12-01), McNamara et al.
patent: 6051835 (2000-04-01), Pettipiece et al.
patent: 6075595 (2000-06-01), Malinen
patent: 6142629 (2000-11-01), Adel et al.
patent: 6160618 (2000-12-01), Garner
patent: 6236881 (2001-05-01), Zahler et al.
patent: 6289229 (2001-09-01), Crowley
patent: 6364829 (2002-04-01), Fulghum
patent: 6373568 (2002-04-01), Miller et al.
patent: 6393315 (2002-05-01), Aprahamian et al.
patent: 6556853 (2003-04-01), Cabib et al.
patent: 6690466 (2004-02-01), Miller et al.
patent: 6821245 (2004-11-01), Cline et al.
patent: 6891613 (2005-05-01), Wolleschensky et al.
patent: 6954667 (2005-10-01), Treado et al.
patent: 2002/0035330 (2002-03-01), Cline et al.
patent: 2003/0081204 (2003-05-01), Cronin et al.
patent: 2003/0135092 (2003-07-01), Cline et al.
patent: 2004/0006275 (2004-01-01), Demos et al.
patent: 2004/0006276 (2004-01-01), Demos et al.
patent: 2004/0081621 (2004-04-01), Arndt et al.
patent: 2004/0225222 (2004-11-01), Zeng et al.
patent: 2005/0065406 (2005-03-01), Cline et al.
patent: 2005/0065440 (2005-03-01), Levenson
patent: 2005/0143627 (2005-06-01), Cline et al.
patent: 2005/0171434 (2005-08-01), Madden et al.
patent: 2006/0074282 (2006-04-01), Ward et al.
patent: 2006/0129040 (2006-06-01), Fine et al.
patent: 2006/0220881 (2006-10-01), Al-Ali et al.
patent: 2006/0241496 (2006-10-01), Fengler et al.
patent: 2007/0015963 (2007-01-01), Fengler et al.
patent: 2007/0016082 (2007-01-01), Levenson et al.
patent: 2007/0080305 (2007-04-01), Maitrejean et al.
patent: 512965 (1992-11-01), None
patent: WO 01/11343 (2001-02-01), None
WO 9918847 A1, Gombrich, Peter P et al., Imaging Diseased Tissue Using Autofluorescence.
R. Cubeddu et al., “Time-gated Fluorescence Spectroscopy and Imaging of Porphyrins and Phthalocyanines”,SPIE,vol. 1525, pp. 17-25, pp. 17-25 (1991).
Silvio Folli et al., “Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice”,Cancer Research,vol. 54, pp. 2643-2649 (May 15, 1994).
M. Kohl et al., “Imaging of tumors by time-delayed laser-induced fluorescence”,SPIE,vol. 1525, pp. 26-34 (1991).
Andre Pelegrin et al., “Antibody-Fluorescein Conjugates for Photoimmunodiagnosis of Human Colon Carcinoma in Nude Mice”,Cancer,vol. 67, pp. 2529-2537 (May 15, 1991).
Karatina Svanberg et al., “Fluorescence Studies of Hematoporphyrin Derivative in Normal and Malignant Rat Tissue”,Cancer Research,vol. 46, pp. 3803-3808 (Aug. 1986).
Eric Van Leengoed et al., “Tissue-Localizing Properties of Some Photosensitizers Studied by in vivo Fluorescence Imaging”,Journal of Photochemistry and Photobiology, B: Biology,vol. 6, pp. 111-119 (1990).
G. Wagnieres et al., “Photodetection of Early Cancer in the Upper Aerodigestive Tract and the Bronchi using Photofrin II and Colorectal Adenocarcinoma with Fluoresceinated Monoclonal Antibodies”,SPIE,vol. 1525, pp. 219-236 (1991).
Nicholas Billinton et al., “Seeing the Wood through the Trees: A Review of Techniques for Distinguishing Green Fluorescent Protein from Endogenous Autofluorescence”,Analytical Biochemistry, vol. 291, pp. 175-197 (2001).
Jacqueline Hewett et al., “The Application of a Compact Multispectral Imaging System with Integrated Excitation Source to In vivo Monitoring of Fluorescence During Topical Photodynamic Therapy of superficial Skin Cancers”,Photochemistry and Photobiology, vol. 73, No. 3, pp. 275-282 (2001).
Luis Jimenez et al., “Supervised Classification in High Dimensional Space: Geometrical, Statistical and Asymptotical Properties of Multivariate Data”,IEEE Transactions on Geoscience and Remote Sensing, vol. 37, No. 6 (Nov. 1999).
W.C. Sweatt et al., “ISIS; An Information-Efficient Spectral Imaging System,” Imaging Spectrometry IV, Proc. SPIE, vol. 3438, pp. 98-106, San Diego, 1998.
B.R. Stallard, Contstruction of Filter Vectors for the Information-Efficient Spectral Imaging Sensor, Imaging Spectroscopy IV, Proc. SPIE, vol. 3438, pp. 172-182, San Diego, 1998.
L.O. Jimenez et al., “High Dimensional Feature Reduction via Projection Pursuit,” TR-ECE 96-5, School of Electrical Engineering, Purdue University, West Lafayette, IN 47907-1285, Apr. 1995.
Hyvarien et al., “Novel Spectroscopic Techniques for Biomedical Applications,” Optoelectronics Laboratory, Finland, SPIE vol. 2084, pp. 224-230.
Keraanen et al., “Thirty-two Channel LED Array Spectrometer Module with Compact Optomechanical Construction,” Technical Research Centre of Finland, Electronics Laboratory, Finland, SPIE vol. 1533 Optomechanics and Dimensional Stability (1991), pp. 122-128.
Gentry et al., Biomedical Applications of the Information-Efficient Spectral Imaging Sensor (ISIS), Gentry, SPIE vol. 3603, pp. 129-142.
Shnitser et al., “Spectrally Adaptive Light Filtering,” Physical Optics Corporation, Torrance, CA, SPIE vol. 3140, pp. 117-127.
Stallard et al., “Construction of Filter Vectors for the Information-Efficient Spectral Imaging Sensor,” Sandia National Laboratories, Albuquerque, NM, SPIE vol. 3438, pp. 172-182.
Sweatt et al., “ISIS: An Information-Efficient Spectral Imaging System,” Sandia National Laboratories, Albuquerque, NM, SPIE Vo. 3438, pp. 98-106.
Jimenez et al., “Supervised Classification in High Dimensional Space: Geometrical, Statistical and Asymptotical Properties of Multivariate Data,” IEEE Transactions on Geoscience and Remote Sensing, vol. 37, No. 6, Nov. 1999; Project in Pursuit in Hyperspectral Data Analysis, Jimenez & Landgrebe, Nov. 23, 1999, pp. 1-32.
P.S. Andersson et al. “Flourescence Endoscopy Instrumentation for Improved Tissue Characterization.” Med. Phys. 14 (4) Jul./Aug. 1987. 633-636.
S. Folli et al. “Immunophotodiagnosis of Colon Carcinomas in Patients Injected with Flouresceinated Chimerica Antibodies Against Carcinoembryionic Antigen.” Institute of Biochemistry, University of Lausanne, Switzerland. 7973-7977.
K.J. Brodbeck et al. “A System for Real Time Flourescence Imaging in Color for Tumor Diagnosis.” Med. Phys. 14 (4) Jul./Aug. 1987 637-639.
David Gillis et al. “Using Endmembers as a Coordinate System in Hyperspectral Imagery.” Naval Research Laboratory, Washington, DC. 1-9.
Andrew A. Green et al. “A Transformation for Ordering Multispectral Data in Terms of Image Quality with Implications for Noise Removal.” IEEE Transactions of Geoscience and Remote Sensing vol. 26, No. 1 Jan.

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