Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-07-26
2005-07-26
Richter, Johann (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
Reexamination Certificate
active
06921840
ABSTRACT:
The present invention is directed to compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein X is hydrogen, Cl, Br, I, NO2, NR3R4or —L—Ch; Y is hydrogen, —CH2OR5, —CH2NCH3R1, NO2, NR3R4or —L—Ch; Y′ is hydrogen, —CH2OH5, —CH2NCH3R1, NO2, NR3R4OR —L—Ch; provided that at least one of the Y or Y′ is —CH2NCH3R1; Z is S, O, NR6CR7R8, C(O) or —C(═CR7R8)-; A is hydrogen, Cl, I, Br or —L—Ch; R1is hydrogen, C1-C5alkyl, C3-C8cycloalkyl C1-5alkylcarbonyl, (C3-C8cycloalkyl) carbonyl, pnenyl, benzyl, naphthyl, naphthylmethyl or L—Ch; R2is hydrogen or methyl; and R3-R8are as defined herein. Radiolabeled compounds of the invention are useful as selective serotonin transporter (SERT) imaging agents for single photon emission tomography (SPECT). As such the compounds are useful for studying the underlying pharmacology and interaction of specific serotinin reuptake site inhibitors (SSRI), commonly used antidepressants, at the SERT sites in the human brain. Certain compounds of the invention, including IDAM (5-iodo-2[[2-2-[(dimethylamino)methyl]phenyl]thio]benzylalcohol) display affinity to SERT sites and show more high selectively for SERT over NET and DAT.
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Nwaonicha Chukwuma
Richter Johann
Sterne Kessler Goldstein & Fox P.L.L.C.
The Trustees of the University of Pennsylvania
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