Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1996-11-15
1998-12-22
Alexander, Lyle A.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
4352883, G01N 3348
Patent
active
058514899
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The invention relates to a specimen slide for a microscope, camera or other such observation device, having a receiving area for cell or tissue samples or other such organic material and further having a smaller observation area for the organic material. The specimen slide at least in the observation area is made of transparent material.
Specimen slides of this character have been known for a long time and enable an organic or biological substance arranged in the receiving area of the specimen slide to be simply positioned together with the specimen slide on the specimen stage of a microscope. The specimen slide is transparent at least in the receiving area in order that light can be transmitted by a light source through the substance under observation during examination with the microscope.
A drawback in this connection is, however, that the organic material under observation has to be arranged in close proximity to the objective of the microscope during examination in order to achieve a sufficient magnification factor and to avoid optical aberrations in the microscope. The organic material, which may be a cell culture for instance, is not easily accessible during examination with the microscope, with the result that it is hardly possible for additional examinations to be carried out on the cell culture of relatively short life under the microscope.
SUMMARY OF THE INVENTION
The object underlying the invention is therefore to provide a specimen slide of the character set forth at the outset, wherein an objective, an illuminating device or other such optical device can be arranged in close proximity to the receiving area and wherein nevertheless a further-reaching examination of the organic material is possible during the optical observation.
This object is accomplished in that within the receiving area, adjacent to the observation area, the specimen slide has at least one thin-film sensor or planar sensor for measuring physiological parameters.
This sensor can be of especially compact design and can be integrated in the specimen slide particularly in the planar technique. Similar to an integrated circuit, the specimen slide can therefore be mass-produced especially simply and cost-advantageously.
In an advantageous way the thin-film or planar sensor adjacent to the observation area enables a further-reaching examination of the organic material by a measuring signal parallel to the optical information obtained for example by examination with a microscope. Due to its low overall height, the sensor can be integrated in the specimen slide or arranged on the surface of the specimen slide, so that sensor and specimen slide form a unit of especial handling facility. The low overall height of the sensor also has especially favourable effects during examination with a microscope, because the objective or condenser lens of a microscope can be brought close to the organic material arranged in the receiving area of the specimen slide, without the objective or condenser lens being obstructed by the sensor. The sensor may be provided by way of example in the form of an ionic concentration sensor for measuring H.sup.+, Na.sup.+, Ca.sup.2+, K.sup.+ or C1 ions, an oxygen sensor, an NO sensor, a CO.sub.2 sensor, a temperature sensor, an interdigital capacitor or reference electrodes. Depending on application, the specimen slide may be equipped with further sensors, particularly optical ones, such as grid couplers for example.
With the use of the specimen slide embodying the invention, important physicochemical parameters of the organic or biological material under observation are made available while at the same time it can be observed, for instance with a microscope. The specimen slide is suited particularly for monitoring and/or measuring the reaction of biological material to various external chemical (e.g. cytostatic agents, changes in ionic concentration, pharmaceuticals, environmental toxicants, washing agents), physical (e.g. temperature changes, electromagnetic fields, irradiation, ac
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patent: 5030418 (1991-07-01), Miyata
patent: 5278048 (1994-01-01), Parce
Clinical Chemistry, Micromachined Analyzers on a Silicon Chip, vol. 40, No. 9, 1994, Philippe Arquint et al., pp. 1805-1809.
Baumann Werner
Dumbs Alfred
Sieben Ulrich
Sulz Gerd
Wolf Bernhard
Alexander Lyle A.
Micronas Intermetall GmbH
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