Specificity of gene expression

Details Specificity of gene expression Specificity of gene expression

1998-03-27

2000-10-31

McElwain, Elizabeth F.

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

The polynucleotide contains a tissue, organ, or cell...

435 691, 4353201, 435419, 435430, 435468, 800286, 800298, C12N 504, C12N 1582, C12N 1590, C12N 1509, A01H 500

Patent

active

06140554&

ABSTRACT:
This invention seeks to improve the specificity of gene expression by targeting a specific expression site of a target gene. There is thus provided a chimaeric gene which comprises a promoter which expresses in more than one region of the organism to be affected. The promoter is linked to an agent which affects the functioning of an endogenous gene in the plant which is also expressed in more than one region of the plant. The promoter and agent are selected so that there is an overlap in their expression sites at one or more desired locations. This overlap site(s) gives increased specificity and targeting of gene expression.

REFERENCES:
Kneissl et al, Plant Physiol., vol. 112, pp. 537-547, 1996.
van der Krol, Nature, vol. 333, jpages 866-869, 1988.
Rochester et al, EMBO J., vol. 5, pp. 451-458, 1986.
Conkling et al., 1990, "Isolation of transcriptionally regulated root-specific genes from tobacco", Plant Physiol. 93:1203-1211.
Opperman et al., 1994, "Root-knot nematode-directed expression of a plant root-specific gene", Science 263:221-223.

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