Specificity in the detection of anti-rubella IGM antibodies

Details Specificity in the detection of anti-rubella IGM antibodies Specificity in the detection of anti-rubella IGM antibodies

2005-03-29

2005-03-29

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S184100, C424S204100, C530S350000, C530S395000, C435S004000, C435S005000, C435S007900, C435S007920

Reexamination Certificate

active

06872396

ABSTRACT:
This invention particularly discloses an improved immunoassay method for the specific detection of anti-rubella IgM antibodies. This method employs rubella antigens comprising rubella E1 and E2 envelope glycoproteins substantially free of capsid protein. Use of this antigen composition reduces or eliminates nonspecific protein-protein interactions leading to false positive results. A sample diluent comprising urea can also be used in the process to further reduce the occurrence of nonspecific protein-protein interactions. A diagnostic kit to aid in the detection of anti-rubella IgM antibodies is also disclosed.

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