Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-11-18
1995-03-21
Alexander, Lyle A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530402, 530410, C07C10352, C07K 1300, A61K 3514
Patent
active
053996712
ABSTRACT:
Hemoglobin is site-specifically crosslinked into its tetrameric form by reaction with a trifunctional reagent which combines electrostatic effects, steric effects and the presence of functional groups so that two of the functional groups react with specific sites on the hemoglobin whilst the third site is left free for reaction with endogenous nucleophilic compounds. A specific example of such a crosslinking reagent is trimesoyl tris(3,5-dibromosalicylate), TTDS, which effects specific crosslinking between the amino groups of lysine-82 on each respective .beta. sub-unit. While the crosslinking reagent TTDS has three available carboxyl groups for the crosslinking reaction, only two so react, leaving one free carboxyl for reaction with exogenous nucleophiles, e.g. to render the hemoglobin product useful as a carrier for nucleophilic compounds through the body's circulatory system.
REFERENCES:
patent: 4529719 (1985-07-01), Tye
patent: 4584130 (1986-04-01), Bucci et al.
patent: 4598064 (1986-07-01), Walder
patent: 4857636 (1989-08-01), Hsia
Kluger Ronald
Song Yonghong
Alexander Lyle A.
Freed Rachel
LandOfFree
Specifically crosslinked hemoglobin with free functionality does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Specifically crosslinked hemoglobin with free functionality, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Specifically crosslinked hemoglobin with free functionality will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1149822