Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-12-09
1997-07-29
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 536 231, 536 232, 536 2431, C07H 2104, C12Q 168
Patent
active
056521014
ABSTRACT:
The invention relates to nucleic acid fragments characterized in that they comprise from 8 to 40 nucleotides and in that their sequence is contained either in the DNA coding sequence of the gene for human villin or in any DNA fragment exactly complementary to one of the former and hence containing the same number of deoxynucleotides, or any corresponding RNA fragment containing the same number of ribonucleotides. The invention also relates to the application of these fragments to a procedure for the in vitro detection of the presence of a nucleic acid characteristic of human villin.
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W.L. Bazari et al.; "Villin sequence and peptide map identify six homologous domains"; Proceedings of the National Academy of Sciences of the United States of America, vol. 85, Jul. 1988, pp. 4986-4990.
E. Andre et al.; "Severin, gelsolin, and villin share a homologous sequence in regions presumed to contain F-actin severing domains"; The Journal of Biological Chemistry, vol. 263, No. 2, (Jan. 15, 1988); pp. 722-727.
S. Robine et al.; "Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells?"; Proceedings of the National Academy of Sciences of the United States of America; vol. 82, (Dec., 1985), pp. 8488-8492.
M. Arpin et al.; "Sequence of human villin in large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity," Journal of Cell Biology, (USA), vol. 107, (Nov. 1988), pp. 1759-1766.
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Arpin Monique
Garcia Alphonse
Louvard Daniel
Pringault Eric
Institut Pasteur
Tran Paul B.
Zitomer Stephanie W.
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