Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1997-06-13
1999-11-23
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4353201, 435 912, 435 691, 435 6, 536 231, 536 232, 536 243, 536 2433, C12N 912, C12N 1552, C12N 1500
Patent
active
059898852
ABSTRACT:
The present invention relates to mutations in the MKK4 gene in human cancers and their use in the diagnosis and prognosis of human cancer. Specific mutations in the MKK4 gene which are associated with breast, pancreatic, colorectal and testicular cancers have been identified. The invention also relates to the therapy of human cancers which have a mutation in the MKK4 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
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Perry, III William L.
Skolnick Mark H.
Tavtigian Sean V.
Teng David H.-F.
Hutson Richard
Myriad Genetics Inc.
Prouty Rebecca E.
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