Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-09-19
1994-02-01
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524026, 53038822, 5303889, 5303879, C07K 1528, C12P 2108, C12N 512
Patent
active
052831906
ABSTRACT:
The present invention provides unique prepared immunogens, site-specific monoclonal antibodies against an epitope of progesterone receptor protein, and an immunoassay to determine the functional integrity of the progesterone receptors in a cellular sample. Collectively or individually the component parts of the invention provide the ability not only to identify accurately the presence of progesterone receptor but also the capability of determining whether the progesterone receptor exists in a clinically normal or abnormal state.
REFERENCES:
patent: 4742000 (1988-05-01), Green
Dicker et al. (1984) J. Steroid Biochem 20, 43-50.
Misrahi et al (1987) Biochem. Biophys. Res. Comm. 143, 740-748.
Walter et al. (1983) in "Genetic Engineering Principles & Methods" (Setlow & Hollaander, eds.) Plenum Publishing Corp. pp. 61-91.
Kearney (1984) in "Fundamental Immunology" (W. E. Paul, ed.) Raven Press, New York, pp. 751-766.
Weigel et al. (1989) Endocrinology 125, 2494-2501.
Smith et al (1988) Endocrinology 122, 2816-2825.
Smith et al (1988) J. Steroid Biochem 30, 1-7.
Edwards et al (1984) Biochemistry 23, 4427-4435.
Traish Adbulmaged M.
Wotiz Herbert H.
Baker R. Keith
Wax Robert A.
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