Specific modulation of Th1/Th2 cytokine expression by ribavirin

Details Specific modulation of Th1/Th2 cytokine expression by ribavirin Specific modulation of Th1/Th2 cytokine expression by ribavirin

1996-01-23

1998-06-16

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 2, 514 46, 514 23, 514 27, 536 291, 536 286, 536 287, A61K 31495, C07H 19167

Patent

active

057670978

ABSTRACT:
Ribavirin is administered to a patient in a dosage range which is effective to modulate lymphokine expression in activated T cells. In particular, ribavirin is used to suppress Th2-mediated T cell responses and promote Th1-mediated T cell response. Thus, instead of administering ribavirin in its well-recognized role as an anti-viral agent, ribavirin is herein used in the treatment of imbalances in lymphokine expression. Such imbalances may be found to be concomitants of allergic atopic disorders such as allergic asthma and atopic dermatitis, helminth infection and leishmaniasis, and various primary and secondary immunodeficiencies, which may or may not also be associated with viral infection.

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