Specific mechanism for inhibiting platelet adhesion to collagen

Details Specific mechanism for inhibiting platelet adhesion to collagen Specific mechanism for inhibiting platelet adhesion to collagen

2004-12-21

2008-12-02

Desai, Anand U (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07459438

ABSTRACT:
The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation after vascular injuries or endarterectomy. The invention furthermore relates to a novel medical use of Saratin as an inhibitor of thrombosis and intimal hyperplasia, where the Saratin polypeptide may be used locally as a topical agent or as a coating on, or otherwise incorporated or associated with medical devices or vascular grafts.

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Barnes CS et al., “Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen,” Seminars in Thrombosis and Hemostasis, vol. 27, No. 4, pp. 337-348, Aug. 2001.

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