Specific inhibitors of tissue kallikrein

Details Specific inhibitors of tissue kallikrein Specific inhibitors of tissue kallikrein

1987-04-03

1989-05-30

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530331, C07K 508, C07K 510

Patent

active

048352535

ABSTRACT:
A unique class of tissue kallikrein inhibitors is provided which are specific for tissue kallikreins and do not substantially cross-react with plasma kallikreins or other serine proteases in-vivo. These inhibitors are substrate analogues of low molecular weight kininogens but are highly inhibitory, stable and resistant to enzymatic hydrolysis, and release non-toxic degradation products.

REFERENCES:
Chem. Abstr. vol. 89, (1978) 38634.
Chem. Abstr. vol. 92 (1980) 193364.
Chem. Abstr. vol. 99 (1983) 35031.
Chem. Abstr. vol. 106 (1987) 152095.
Chem. Abstr. vol. 103 (1985) 34004.
Chem. Abstr. vol. 105 (1986) 74765.

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