Specific inhibitors of tissue kallikrein

Details Specific inhibitors of tissue kallikrein Specific inhibitors of tissue kallikrein

1993-06-22

1995-11-07

Warden, Jill A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530329, 530331, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

054648203

ABSTRACT:
The invention is directed to substrate analogs which are specific for tissue kallikrein. These analogs contain a sequence which corresponds to at least positions 388 to 390 of human kininogen, and which has a 4-aminophenylalanine (Phe(4NH.sub.2)), or a structurally or functionally similar residue, corresponding to position 389. These substrate analogs are useful in compositions and methods for the treatment or prevention of biological activities associated with tissue kallikrein including inflammation, the regulation of blood flow, the regulation of proenzyme activity through processing, shock, hypotension, vascular leakage, and the perception of pain.

REFERENCES:
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patent: 4835253 (1989-05-01), Burton
Everest et al. J. Med. Microbiol. vol. 38 p. 316 (1993)-abstract only.
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