Specific inhibition of angiotensin-II binding to angiotensin-II

Details Specific inhibition of angiotensin-II binding to angiotensin-II Specific inhibition of angiotensin-II binding to angiotensin-II

1991-11-21

1992-12-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514215, 514216, 514397, 514398, A61K 3144, A61K 3155, A61K 31415

Patent

active

051734940

ABSTRACT:
4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridine derivatives such as 1-(4-amino-3-methylphenyl) methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-car boxylic acid are useful for treatment of CNS disorders, such as cognitive and learning disorders, mediated by angiotensin-II.

REFERENCES:
patent: 4301169 (1981-11-01), Yamanaka et al.
patent: 4402966 (1983-09-01), Yamanaka et al.
patent: 4533669 (1985-08-01), Yamanaka et al.
patent: 4602031 (1986-07-01), Yamanaka et al.
patent: 4812462 (1989-03-01), Blankley et al.
Mann. Exp. Brain Res.. vol. 4, suppl. pp. 242, 1982.
Fitzsimons, Rev. Physiol. Biochem. Pharmacol., vol. 87, pp. 117, 1980.
Scholken et al., Experientia., vol. 38, pp. 469, 1982.
Koller, et al., Neuroscience Lett., vol. 14, pp. 71-75, 1975.
Morgan and Routtengerg, Science, vol. 196, pp. 87-89, 1977.
Arregui, et al., J. Neurochem, vol. 38, pp. 1490-1692, 1982.
Zubenko, et al., Biol. Psych., vol. 21, pp. 1365-1381, 1986.
Usinger, et al., Drug Dev. Research, vol. 14, pp. 315-324, 1988.
Costall, et al., Pharmacol. Biochem. Behav., vol. 33, pp. 573-579, 1989.
Barnes et al., Brain Research, vol. 491, pp. 136-143, 1989.
Chiu, et al., Biochem. and Biophys. Res. Comm., vol. 165, pp. 196-203, 1989.
Whitebread, et al., Biochem and Biophys. Res. Comm., vol. 163, pp. 284-291, 1989.
Bennet and Snyder, J. Biol. Chem., vol. 254, pp. 7423-7430, 1976.
Unger et al., Circulation, vol. 77 (suppl. I) pp. 40-54, 1988.

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