Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Patent
1992-11-18
1997-07-29
Feisee, Lila
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
514825, 514866, 424 857, A61K 3514
Patent
active
056519931
ABSTRACT:
Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance expression of a major histocompatibility complex molecule and reacting the treated antigen presenting cell with the antigen extracorporeally to form an antigen-associated antigen presenting cell.
REFERENCES:
patent: 4684521 (1987-08-01), Edelson et al.
patent: 4838852 (1989-06-01), Edelson et al.
patent: 5114721 (1992-05-01), Cohen et al.
patent: 5147289 (1992-09-01), Edelson et al.
Malawista, et. al. 1991. Annals New York Acad. Sci. pp. 217-225.
Osbaird, M.E. 1990. Immunol. Today 11: 193-195.
Edelson, et al. 1991. Annals New York Acad. Sci. 636: 154-164.
Fundamental Immunology 2.sup.nd ed Raven Press W. Paul. 1989 pp. 546-567.
Cohen et al. Science 262: 841-843 Nov. 5, 1993.
Edelson, R., "Photopheresis: A Clinically Relevant Immunobiologic Response Modifier," Annals of N.Y. Academy of Sciences 636:154-164 (1991).
Ljunggren et al., "Empty MHC class 1 molecules come out in the cold," Nature 346:476-480 (1990).
Rock et al., "Reassociation with .beta..sub.2 -microglobulin is necessary for Kb class 1 major histocompatibility complex binding of exogenous peptides," Proc. Natl. Acad. Sci. (USA) 87:7517-7521 (1990).
Essential Immunology, seventh edition, Blackwell Scientific Publications, Oxford, Great Britain, pp. 26-31 and 140-150 (1991) (Roitt).
Edelson, R., "Light-activated Drugs," Scientific American 256(8):68-75 (1988).
Rook, A., "Photopheresis in the Treatment of Autoimmune Disease: Experience with Pemphigus Vulgaris and Systemic Sclerosis," Annals of N.Y. Academy of Science 636:209-216 (1991).
Malawista, S., et al., "Photopheresis for Rheumatoid Arthritis," Annals of N.Y. Academy of Science 636:217-226 (1991).
Perez, M., et al., "Inhibition of Antiskin Allograft Immunity Induced by Infusions with Photoinactivated Effector T Lymphocytes (PET Cells); The Congenic Model," Transplantation 51:1283-1289 (1991).
Bisaccia, E., et al., "Viral-Specific Immunization in AIDS-Related Complex by Photopheresis," Annals of N.Y. Academy of Science 636:321-330 (1991).
Ben-Nun, A., et al., "Vaccination against autoimmune encephalomyelitis with T lymphocyte line cells reactive against myelin basic protein," Nature 292:60-61 (1981).
Holoshitz, J., et al., "Lines of T lymphocytes induce or vaccinate against autoimmune arthritis," Science 219:56-58 (1983).
Lider, O., et al., "Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis," Science 239:181-183 (1988).
Khavari, P., et al., "Specific vaccination against photoinactivated cloned T cells," Abstract Clin. Res. 36:662A (1988).
Edelson, R., et al., "Treatment of cutaneous T cell lymphoma by extracorporeal photochemotherapy," N. Engl. J. Med. 316:297-303 (1987).
Boon, P., "Toward a Genetic Analysis of Tumor Rejection Antigens" Adv. Cancer Res. 58:177-210 (1992).
Latron, F., "A Critical Role for Conserved Residues in the Cleft of HLA-A2 in the Presentation of a Nonapeptide to T-cells," Science 257:964-967 (1992).
Malane, M. and Gasparro, R., "T Cell Molecular Targets for Psoralens," Annals of N.Y. Academy of Science 636:196-208 (1991).
Heald, P.W., "Photopheresis for Cutaneous T Cell Lymphoma," Annals New York Academy of Sciences 636:171-177 (1991).
Calzavara-Pinton, et al., "A Reappraisal of the Use of 5-Methoxy-psoralen in the Therapy of Psoriasis," Exptl. Dermatol. 1:46-51 (1992).
Yang, et al., "8-MOP DNA Photoadducts in Patients Treated with 8-MOP and UVA," J. Invest. Dermatol. 92:59-63 (1989).
Berger, C., et al., "Comparison of Synthetic Psoralen Derivatives and 8-MOP in the Inhibition of Lymphocyte Proliferation," Annals of N.Y. Academy of Science 453:80-90 (1985).
Jenkins, M.K., "The Role of Cell Division in the Induction of Clonal Anergy," Immunology Today 13:69-73 (1992).
Gerometta, J.S., et al., "UVB radiation inactivates a co-stimulatory factor expressed on the surface of Langerhans cells, thus rendering them capable of inducing clonal anergy in CD4+ cells," J. Invest. Dermatol. 96:626 (abstract) (1991).
van Iperen, H.P. and Beijersbergen van Henegouwen, "An animal model for extracorporeal photochemotherapy based on contact hypersensitivity," J. Photochem. Photobiol. B:Biol. 15:361-366 (1992).
Berger, C.L., et al., "Autoregulation of the Immune Response in Autoimmune Disease and Cardiac Transplantation by Photoinactivated Autologous Lymphocytes," Annals New York Academy of Sciences 636:246-278 (1991).
van Pel, A., et al., "Tum-Antigens, TSTA, and T Cell Immune Surveillance," Annals New York Academy of Sciences 636:43-51 (1991).
Tsomides, T. et al., Naturally Processed Viral Peptides Recognized by Cytotoxic T Lymphocytes on Cells Chronically Infected by Human Immunodeficiency Virus Type 1, J. Exp. Med. 180:1283-1293 (1994).
Kannagi, M. et al., Expression of the Target Antigen for Cytotoxic T Lymphocytes on Adult T-cell Leukemia Cells, Int. J. Cancer 54:582-588 (1993).
Roitt, I., Essential Immunology, 7th Ed., Blackwell Scientific Publications, Oxford, England, 1991, pp. 120-127.
Edelson Richard L.
Gasparro Francis P.
Tigelaar Robert E.
Davis Minh-Tam B.
Feisee Lila
Yale University
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