Specific GRP78 expression-inhibition RNAi sequence, medicine...

Details Specific GRP78 expression-inhibition RNAi sequence, medicine... Specific GRP78 expression-inhibition RNAi sequence, medicine...

2009-04-30

2010-11-02

Bowman, Amy (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024500, C435S320100

Reexamination Certificate

active

07825100

ABSTRACT:
The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.

REFERENCES:
patent: 6506559 (2003-01-01), Fire et al.
patent: 2005/0118625 (2005-06-01), Mounts

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