Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-07-17
2010-11-09
Bowman, Amy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C536S023100, C514S04400A
Reexamination Certificate
active
07829695
ABSTRACT:
The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.
REFERENCES:
patent: 6506559 (2003-01-01), Fire et al.
Chang Joseph T.
Cheng Ann-Joy
Chiu Ching-Chi
Bowman Amy
Chang Gung University
Muncy Geissler Olds & Lowe, PLLC
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