Specific detection of cell surface receptor leukocyte adhesion m

Details Specific detection of cell surface receptor leukocyte adhesion m Specific detection of cell surface receptor leukocyte adhesion m

1992-04-02

1995-02-14

Saunder, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 2, 4352402, 436548, G01N 33577

Patent

active

053895207

ABSTRACT:
A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis are disclosed. Also disclosed are methods for the specific detection of cell-surface bound LAM-1 in the presence of shed LAM-1 and for immunotherapy using monoclonal antibodies reactive with cell-surface bound LAM-1 but not reactive with shed LAM-1.

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