Specific co-activator for human androgen receptor

Details Specific co-activator for human androgen receptor Specific co-activator for human androgen receptor

1996-05-23

1998-08-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 435366, C12Q 168, C12N 510, C12N 1579

Patent

active

057891702

ABSTRACT:
A ligand dependent co-activator for the human androgen receptor has been identified. The co-activator, named here ARA.sub.70, potentiates interaction between androgens and the receptor. The co-activator is useful as a tool in monitoring the androgenic/antiandrogenic effects of possible pharmaceuticals as well as environmental samples. The cDNA for co-activator has been cloned and sequenced.

REFERENCES:
Chang, Chawnshang, et al., "Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors," Proc. Natl. Acad. Sci. USA, 85:7211-7215 (Oct. 1988).
Santoro, Massimo, et al., "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma," Activation of RET/PTC3 in Thyroid Carcinomas, pp. 509-516 (Sep. 14, 1993).
Yeh, Shuyuan, et al., "Cloning and Characterization of a Specific Coactivator, ARA.sub.70, for the Androgen Receptor in Human Prostate Cells," Proc. Natl. Acad. Sci. USA, 93:5517-521 (May 1996).
Young, Win-jing, et al., "Quantitation of androgen receptor mRNA by competitive reverse transcription-polymerase chain reaction," Endocrine Journal, 2:321-329 (1994).

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