Specific caspase-10 inhibitors

Details Specific caspase-10 inhibitors Specific caspase-10 inhibitors

2005-11-02

2010-11-09

Kwon, Brian-Yong S (Department: 1614)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S277000, C514S570000, C562S492000

Reexamination Certificate

active

07829721

ABSTRACT:
The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.

REFERENCES:
patent: 5352788 (1994-10-01), Bernhart et al.
patent: 2004/0034064 (2004-02-01), Kuduk et al.
patent: 3026402 (1982-02-01), None
patent: 56125339 (1981-10-01), None
patent: WO 93/15717 (1993-08-01), None
patent: WO 93/15732 (1993-08-01), None
patent: WO 01/39792 (2001-06-01), None
patent: WO 01/81312 (2001-11-01), None
Boye et al. Helv Chim Acta, 72: 1690-1696, 1989.
English translation of JP-56125339 abstract.
Boye O et al : << Natural Products. Antitubulin Effect of Congeners of N-Acetylcolchinyl Methyl Ether : Synthesis of Optically Active 5-Acetamidodeaminocolchinyl Methyl Ehter and of Demethoxy Analogues of Deaminocolchinyl Methyl Ether >> Canadian Journal of Chemistry, National Research Council, Ottowa, CA, vol. 70, No. 5, 1992, pp. 1237-1249, XP009047355 ISSN : 0008-4042 cited in the application compounds, 19, 36 p. 1245 ; compound 19 p. 1247; compound 36.

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