Specific binding members, materials and methods

Details Specific binding members, materials and methods Specific binding members, materials and methods

1996-05-23

1999-02-16

Saunders, David

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303875, 5303877, 53038815, 53038885, 5303897, 5303913, 435 723, C12P 2108, C07K 1632, G01N 33574

Patent

active

058722157

ABSTRACT:
Specific binding members for human carcinoembryonic antigen (CEA) comprise a human antibody antigen binding domain. The specific binding members may have a dissociation constant less than 1.0.times.10.sup.-8 M and may be substantially non-crossreactive with human liver and/or other normal tissues. They may be specific for the A3-B3 extracellular domain of CEA. They may be specific for a carbohydrate epitope of CEA. They may be produced by recombinant expression from encoding nucleic acid and modified and manipulated in various manners in accordance with known techniques. CEA is a tumour antigen and the specific binding members have proven ability to bind and target CEA both in vitro and in vivo.

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