Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-12-19
2006-12-19
Helms, Larry R. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500, C530S388850, C530S387100, C530S388150, C424S124000, C424S156100, C424S133100, C424S155100, C424S130100
Reexamination Certificate
active
07151169
ABSTRACT:
The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGFβ1and are useful in treating conditions associated with excess TGFβ1activity, such as fibrosis, immune responses and tumor progression.
REFERENCES:
patent: 4634666 (1987-01-01), Engleman et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5262319 (1993-11-01), Iwata et al.
patent: 5395750 (1995-03-01), Dillon et al.
patent: 5571714 (1996-11-01), Dasch et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5614367 (1997-03-01), Kaluza et al.
patent: 5616561 (1997-04-01), Barcellos-Hoff
patent: 5662904 (1997-09-01), Ferguson et al.
patent: 5688504 (1997-11-01), Morgan, Jr.
patent: 5739277 (1998-04-01), Presta et al.
patent: 5772998 (1998-06-01), Dasch et al.
patent: 5783181 (1998-07-01), Browne et al.
patent: 5783185 (1998-07-01), Dasch et al.
patent: 5824297 (1998-10-01), Iwata et al.
patent: 5871724 (1999-02-01), Iwata et al.
patent: 5885793 (1999-03-01), Griffiths et al.
patent: 6090383 (2000-07-01), Dasch et al.
patent: 6248516 (2001-06-01), Winter et al.
patent: 6331415 (2001-12-01), Cabilly et al.
patent: 6419928 (2002-07-01), Dasch et al.
patent: 2005/0049403 (2005-03-01), Thompson et al.
patent: B-27617/88 (1989-07-01), None
patent: A 0120694 (1984-10-01), None
patent: A 0125023 (1984-11-01), None
patent: A 184187 (1986-06-01), None
patent: A 239400 (1987-09-01), None
patent: 0324162 (1988-12-01), None
patent: 0368684 (1994-03-01), None
patent: 2188638 (1987-10-01), None
patent: 2 288 118 (1995-10-01), None
patent: 2 305 921 (1997-04-01), None
patent: 06165692 (1994-06-01), None
patent: 06165692 (1994-06-01), None
patent: WO 88/06630 (1988-09-01), None
patent: WO 88/09344 (1988-12-01), None
patent: WO 90/02809 (1990-03-01), None
patent: WO 90/05144 (1990-05-01), None
patent: WO 90/14424 (1990-11-01), None
patent: WO 90/14430 (1990-11-01), None
patent: WO 90/14443 (1990-11-01), None
patent: WO 91/04748 (1991-04-01), None
patent: WO 91/09967 (1991-07-01), None
patent: WO 91/10737 (1991-07-01), None
patent: WO 91/17271 (1991-11-01), None
patent: WO 92/00330 (1992-01-01), None
patent: WO 92/01047 (1992-01-01), None
patent: WO 92/06204 (1992-04-01), None
patent: WO 92/09690 (1992-06-01), None
patent: WO 92/17206 (1992-10-01), None
patent: WO 92/18619 (1992-10-01), None
patent: WO 92/20791 (1992-11-01), None
patent: WO 93/06213 (1993-04-01), None
patent: WO 93/11161 (1993-06-01), None
patent: WO 93/11236 (1993-06-01), None
patent: WO 93/14782 (1993-08-01), None
patent: WO 93/17708 (1993-09-01), None
patent: WO 93/19783 (1993-10-01), None
patent: WO 93/21945 (1993-11-01), None
patent: WO 94/13804 (1994-06-01), None
patent: WO 94/18227 (1994-08-01), None
patent: WO 95/13827 (1995-05-01), None
patent: WO 97/13844 (1997-04-01), None
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
Supplemental Search Report of Corresponding European Application No. 04014972.6, dated Dec. 12, 2004.
Burmester, James K., et al., “Mutational Analysis of a Transforming Growth Factor-β Receptor Binding Site,”Growth Factors, Harwood Academic Publishers, vol. 15, No. 3, 1998, pp. 231-242.
Flanders, Kathleen, C., et al., “Antibodies to Peptide Determinants in Transforming Growth Factor β and Their Applications,”Biochemistry, American Chemical Society, 1988, vol. 27, 739-746.
Hoefer, Magdalene, et al., “Anti-Transforming Growth Factorβ) Antibodies With Predefined Specificity Inhibit Metastasis of Highly Tumorigenic Human Xenotransplants in nu
u Mice,”Cancer Immunology and Immunotherapy, vol. 41, No. 5, 1995, 302-308.
Su Wen Qian, et al., “Binding Affinity of Transforming Growth Factor-Beta for its Type II Receptor is Determined by the C-Terminal Region of the Molecule,”Journal of Biological Chemistry, American Society of Biological Chemists, vol. 271, No. 48, Nov. 29, 1996, 30656-30662.
R&D Systems Inc. Catalog, “Monoclonal Anti-human TGF-β1 Antibody”, Catalog No. MAG240, Jun. 20, 2000, pp. 1-2.
Oncogene Research Products, Transforming Growth Factorβ1 (Ab-1) Monoclonal Antibody, Catalog No. GF33L.
R&D Systems, Inc. Catalog, Monoclonal Anti-human TGF-β1 Antibody, Catalog No. MAB2401, Jan. 30, 2002, pp. 1-2.
R&D Systems, Inc. Catalog, Monoclonal Anti-TGF-β2 Antibody, Catalog No. MAB612, Jun. 28, 2001, pp. 1-2.
R&D Systems, Inc. Catalog, Monoclonal Anti-TGF-β3 Antibody, Catalog No. MAB243, Nov. 15, 2000, pp. 1-2.
R&D Systems, Inc. Catalog, Monoclonal Anti-TGF-β3 Antibody, Catalog No. MAB643, Jun. 21, 2001, pp. 1-2.
Data Specification Sheet—Chemicon International, Catalog No. MAB1032, “Mouse Anti-Human Transforming Growth Factorβ (TGFβ) Monoclonal Antibody.”
Yes Biotech Laboratories, Ltd. Website homepage—http://www.yesbiotech.com/index.html.
Monoclonal Antibodies: Murine Anti-Human TGFβ data sheet—Thursday, Feb. 7, 2002, Yes Biotech Laboratories Ltd. Website: http://www.yesbiotech.com/tech14.htm.
RDI—Research Diagnostics, Inc. Website homepage—Thursday, Feb. 7, 2002; Quick Access to Links for On Line Spec Sheets—http://www.researchd.com/index.htm.
Cytokines, Growth Factors Chemokines: Antibodies: and Mouse Monoclonal Antibody to Human TFG-β (Oct. 3, 2001)—RDI—Research Diagnostics, Inc. Website homepage—Thursday, Feb. 7, 2002; Links for On Line Spec Sheets—http://www.researchd.com/cytokines/lgfbab.htm.
Catalog No. M700022, Mouse Anti-Human TGFβ(2C5); Antigenix America, Inc.; http://www.SciQuest.com/cgi-bin
commerce3/ExecMacro/product—details.d2w/report?Tmstmp=1013101956096&Refresh=N, Thursday, Feb. 7, 2002.
Catalog No. MO-C40009.D, Mouse Anti-Human TGFβMonoclonal Antibody, Clone No. 2C6; Anogen/Yes Biotech Laboratories Ltd.; http://www.SciQuest.com/cgi-bin
commerce3/ExecMacro/product—details.d2w/report?Tmstmp=1013102046067&; Thursday, Feb. 7, 2002.
Catalog No. MO-C40009.E, Mouse Anti-Human TGFβ Monoclonal Antibody, Clone No. 2E6; Anogen/Yes Biotech Laboratories Ltd.; http://www.SciQuest.com/cgi-bin
commerce3/ExecMacro/product—details.d2w/report?Tmstmp=1013102046067&; Thursday, Feb. 7, 2002.
Catalog No. MO-C40009.F, Mouse Anti-Human TGFβ Monoclonal Antibody, Clone No. 8C4; Anogen/Yes Biotech Laboratories Ltd.; http://www.SciQuest.com/cgi-bin
commerce3/ExecMacro/product—details.d2w/report?Tmstmp=1013102046067&; Thursday, Feb. 7, 2002.
Catalog No. MO-C40009.H, Mouse Anti-Human TGFβ Monoclonal Antibody, Clone No. 4C2; Anogen/Yes Biotech Laboratories Ltd.; http://www.SciQuest.com/cgi-bin
commerce3/ExecMacro/product—details.d2w/report?Tmstmp=1013102046067&; Thursday, Feb. 7, 2002.
Oncogene Research Products website—Catalog No. GF16—Transforming Grwoth Factorβ3 (Ab-1) Monoclonal Antibody, http://www.apoptosis.com/products/ProductDetail—ONC.asp?catNO=GF16, Feb. 7, 2002.
ATCC, Welcome to the Monoclonal Connection (Hybridoma Data Bank)—What is the Hybridoma Data Bank (HDB), http:/www/atcc:org/SearchCatalogs/hdbcfm, pp. 1-2, Feb. 7, 2002.
ATCC Search “TGFb” Catalog No. 1024236 Re: 1 G>Homo sapiens1, CN>human an 1024236—http://phage.atcc.org/cgi-bin/searchengine/hdb/Longview.cgl?view=/pub/textfiles/hdb-di.out.17906760&text=TGFb, Feb. 7, 2002.
ATCC Search “TGFb”Catalog No. 1024691 Re: 1 G>Homo sapiens1, CN>human an 1024691—http://phage.atcc.org/cgi-bin/searchengine/hdb/Longview.cgl?view=/pub/textfiles/hdb-di.out.17906760&text=TGFb, Feb. 7, 2002.
Abstract, Dasch, J. R., et al., “Monoclonal antibodies recognizing transforming growth factor-beta.Bioa
Braddock Peta Sally Helena
Conroy Louise Anne
Du Fou Sarah Leila
Lennard Simon Nicholas
McCafferty John Gerald
Cambridge Antibody Technology Limited
Clough David W.
Helms Larry R.
Howrey LLP
Tungaturthi Parithosh K.
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