Specific binding assays employing label analog to reduce sample

Details Specific binding assays employing label analog to reduce sample Specific binding assays employing label analog to reduce sample

1986-04-16

1989-03-07

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436825, 536 22, 536 24, 435810, G01N 3353, C07H 1900, C07H 1700, C07H 2100

Patent

active

048106356

ABSTRACT:
A specific binding assay, e.g., immunoassay, method and reagent system wherein a structural analog of the label portion of the labeled reagent is included in the reaction mixture to interact with potentially interfering substances in the test sample. The label analog is selected or designed to be substantially inactive in the assay detection system. The invention improves the precision of the assays, particularly homogeneous immunoassays, by significantly reducing or eliminating the variable interaction, e.g., binding, of the labeled reagent by interfering substances in the test sample.

REFERENCES:
patent: 4238565 (1980-12-01), Hornby et al.
patent: 4318983 (1982-02-01), Hornby et al.
patent: 4582791 (1986-04-01), Khanna et al.
patent: 4666831 (1987-05-01), Janoff et al.

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